I've done nearly 1000 miles on my V4S and I can't say I've had an issue with the heat. I wear full leathers and don't notice any heat, either through the seat or on my legs. This opinion comes from not only riding around town but also includes a 2 day, 500 mile boys weekend trip riding hard alongside sports cars. I went out with a pair of kevlar bike jeans on for a short ride, and yep at that point I felt the heat at that point, so obvious suggestion is to wear leathers.
I don't see it mentioned much, but the mirror vibration is truly awful, in my experience to an almost unusable level - when I do see it mentioned it's often disregarded as an unnecessary issue, but I value my mirrors for safety as I'm sure others do. I don't like bar end mirrors so if anyone has a recommendation on aftermarket mirrors I'd appreciate it.
Other observations are low speed riding off 1st gear through towns sub 20/30mph is hard work, got to ride the clutch a lot to keep it smooth. A 'Ducati-ism' that I had on my monster and 748 back in the day so no real surprise.
In every other respect this bike is amazing.